Molecular weight (DA)
82kD
Immunogen
Synthesized peptide derived from human QSOX1
Specificity
This antibody detects endogenous levels of QSOX1 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide . Plays a role in disulfide bond formation in a variety of extracellular proteins . In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration .
Gene Name
QSOX1 QSCN6 UNQ2520/PRO6013
Protein name
Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6)
Human protein sequence Database
O00391
Mouse protein sequence database
Q8BND5
Rat protein sequence database
Q6IUU3
Cellular localization
[Isoform 1]: Golgi apparatus membrane ; Single-pass membrane protein . Secreted . A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. .; [Isoform 2]: Secreted . Found in the extracellular medium of quiescent cells but is not found in proliferating cells. .
Tissue expression
Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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