Molecular weight (DA)
16kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 50-147
Specificity
This antibody detects endogenous levels of AIF1 protein.
Source
Monoclonal, Mouse IgG1, Kappa
Formulation
PBS, pH7.4, 50% glycerol, 0.05% Proclin 300
Dilution rate
IHC-p 1:200-400, WB 1:500-2000, ELISA 1:5000-20000
Purification process (Immunogen)
Protein G
Background
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016],
Function
function:May play a role in macrophage activation and function.,PTM:Phosphorylated on serine residues.,similarity:Contains 2 EF-hand domains.,
Protein name
Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1)
Other name
AIF 1;AIF-1;Aif1;AIF1 protein;AIF1_HUMAN;Allograft inflammatory factor 1;Allograft inflammatory factor 1 splice variant G;allograft inflammatory factor-1 splice variant Hara-1;balloon angioplasty responsive transcription;BART 1;G1;G1 putative splice variant of allograft inflamatory factor 1;IBA 1;IBA1;interferon gamma responsive transcript;Interferon responsive transcript 1;interferon responsive transcript factor 1;Ionized calcium binding adapter molecule 1;Ionized calcium-binding adapter molecule 1;ionized calcium-binding adapter molecule;IRT 1;IRT1;Microglia response factor;MRF1;Protein g1;
Human protein sequence Database
P55008
Mouse protein sequence database
O70200
Rat protein sequence database
P55009
Cellular localization
Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, phagocytic cup . Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. .
Tissue expression
Detected in T-lymphocytes and peripheral blood mononuclear cells.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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