Molecular weight (DA)
27kD
Immunogen
Synthesized peptide derived from human DIO1
Specificity
This antibody detects endogenous levels of DIO1 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Gene Name
DIO1 ITDI1 TXDI1
Protein name
Type I iodothyronine deiodinase (EC 1.97.1.10) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase)
Human protein sequence Database
P49895
Mouse protein sequence database
Q61153
Rat protein sequence database
P24389
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)