Molecular weight (DA)
78kD
Immunogen
Synthesized peptide derived from human CAPRIN1
Specificity
This antibody detects endogenous levels of CAPRIN1 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Gene Name
CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105
Protein name
Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI)
Human protein sequence Database
Q14444
Mouse protein sequence database
Q60865
Rat protein sequence database
Q5M9G3
Cellular localization
Cytoplasm, cytosol . Cell projection, dendrite . Cell projection, lamellipodium . Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330). .
Tissue expression
Ubiquitous.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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