Immunogen
The antiserum was produced against synthesized peptide derived from human CIDEC. AA range:189-238
Specificity
CIDE-3 Polyclonal Antibody detects endogenous levels of CIDE-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cell death inducing DFFA like effector c(CIDEC) Homo sapiens This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
Function
function:Isoforms 1 and 2 induce apoptosis.,similarity:Contains 1 CIDE-N domain.,subcellular location:Cytoplasmic in a punctate manner.,tissue specificity:Expressed mainly in small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.,
Protein name
Cell death activator CIDE-3
Other name
CIDEC; FSP27; Cell death activator CIDE-3; Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27 homolog
Human protein sequence Database
Q96AQ7
Mouse protein sequence database
P56198
Rat protein sequence database
Cellular localization
Nucleus . Endoplasmic reticulum. Lipid droplet. Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
Tissue expression
Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
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