Immunogen
The antiserum was produced against synthesized peptide derived from human F111B. AA range:281-330
Specificity
FAM111B Polyclonal Antibody detects endogenous levels of FAM111B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/200. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014],
Function
sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the FAM111 family.,
Protein name
Protein FAM111B
Other name
FAM111B; CANP; Protein FAM111B; Cancer-associated nucleoprotein
Human protein sequence Database
Q6SJ93
Mouse protein sequence database
Rat protein sequence database
Tissue expression
Widely expressed.
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