Molecular weight (DA)
160kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LEG7. AA range:41-90
Specificity
Galectin-7 Polyclonal Antibody detects endogenous levels of Galectin-7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008],
Function
function:Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.,induction:By p53.,online information:Galectin-7,similarity:Contains 1 galectin domain.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Monomer.,tissue specificity:Mainly in stratified squamous epithelium.,
Other name
LGALS7; PIG1; LGALS7B; Galectin-7; Gal-7; HKL-14; PI7; p53-induced gene 1 protein
Human gene ID
3963/653499
Human protein sequence Database
P47929
Mouse protein sequence database
O54974
Rat protein sequence database
P97590
Cellular localization
Cytoplasm . Nucleus . Secreted . May be secreted by a non-classical secretory pathway.
Tissue expression
Mainly expressed in stratified squamous epithelium.
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