Molecular weight (DA)
66kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GNL3L. AA range:71-120
Specificity
GNL3L Polyclonal Antibody detects endogenous levels of GNL3L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010],
Function
domain:In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.,function:Required for normal processing of ribosomal pre-rRNA. Required for cell proliferation. Binds GTP.,similarity:Belongs to the MMR1/HSR1 GTP-binding protein family.,
Protein name
Guanine nucleotide-binding protein-like 3-like protein
Other name
GNL3L; Guanine nucleotide-binding protein-like 3-like protein
Fields
>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
Q9NVN8
Mouse protein sequence database
Q6PGG6
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Lung,Skin,
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