Molecular weight (DA)
319kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600
Specificity
Neurofibromin Polyclonal Antibody detects endogenous levels of Neurofibromin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,caution:Was originally (PubMed:8807336) thought to be associated with LEOPARD (LS), an autosomal dominant syndrome.,disease:Defects in NF1 are a cause of familial spinal neurofibromatosis (spinal NF) [MIM:162210]. Familial spinal NF is considered to be an alternative form of neurofibromatosis, showing multiple spinal tumors.,disease:Defects in NF1 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Germline mutations of NF1 account for the association of JMML with type 1 neurofibromatosis (NF1).,disease:Defects in NF1 are a cause of neurofibromatosis-Noonan syndrome (NFNS) [MIM:601321]. NFNS is characterized by manifestations of both NF1 and
Protein name
Neurofibromin
Abbreviation
Neurofibromin
Other name
NF1; Neurofibromin; Neurofibromatosis-related protein NF-1
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>MAPK signaling pathway;>>Ras signaling pathway
Human protein sequence Database
P21359
Mouse protein sequence database
Q04690
Rat protein sequence database
P97526
Cellular localization
Nucleus . Nucleus, nucleolus .
Tissue expression
Detected in brain, peripheral nerve, lung, colon and muscle.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车