Molecular weight (DA)
130kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NOL8. AA range:1118-1167
Specificity
Nop132 Polyclonal Antibody detects endogenous levels of Nop132 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008],
Function
function:Plays an essential role in the survival of diffuse-type gastric cancer cells. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.,induction:Up-regulated in diffuse-type gastric cancers.,PTM:Phosphorylated.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7.,tissue specificity:Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.,
Protein name
Nucleolar protein 8
Other name
NOL8; C9orf34; NOP132; Nucleolar protein 8; Nucleolar protein Nop132
Human protein sequence Database
Q76FK4
Mouse protein sequence database
Q3UHX0
Rat protein sequence database
Cellular localization
Nucleus, nucleolus . Localizes in the nucleolar-organizing region during ribosome biogenesis.
Tissue expression
Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.
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