Immunogen
The antiserum was produced against synthesized peptide derived from human TPIP1. AA range:75-124
Specificity
p53AIP1 Polyclonal Antibody detects endogenous levels of p53AIP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
Function
function:May play an important role in mediating p53/TP53-dependent apoptosis.,induction:By p53/TP53.,tissue specificity:Only found to be expressed in thymus.,
Protein name
p53-regulated apoptosis-inducing protein 1
Other name
TP53AIP1; p53-regulated apoptosis-inducing protein 1; p53AIP1
Fields
>>p53 signaling pathway;>>Apoptosis
Human protein sequence Database
Q9HCN2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Only found to be expressed in thymus.
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