Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FGF13. AA range:154-203
Specificity
FGF-13 Polyclonal Antibody detects endogenous levels of FGF-13 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008],
Function
function:Probably involved in nervous system development and function.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Nervous system.,
Protein name
Fibroblast growth factor 13
Other name
FGF13; FHF2; Fibroblast growth factor 13; FGF-13; Fibroblast growth factor homologous factor 2; FHF-2
Human protein sequence Database
Q92913
Mouse protein sequence database
P70377
Rat protein sequence database
Q9ERW3
Cellular localization
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . Nucleus .; [Isoform 3]: Cytoplasm . Nucleus .; [Isoform 4]: Cytoplasm . Nucleus .; [Isoform 5]: Cytoplasm . Nucleus .; Cell projection, filopodium . Cell projection, growth cone . Cell projection, dendrite . Cell membrane, sarcolemma . Cytoplasm . Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. .
Tissue expression
Ubiquitously expressed. Predominantly expressed in the nervous system.