Molecular weight (DA)
87kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TACC1. AA range:11-60
Specificity
TACC1 Polyclonal Antibody detects endogenous levels of TACC1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009],
Function
alternative products:Additional isoforms seem to exist,developmental stage:Expressed at high level during early embryogenesis.,function:Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.,miscellaneous:Down-regulated in a subset of cases of breast cancer.,PTM:Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TACC family.,similarity:Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.,subcellular location:Nucleus during interphase. Weakly concentrated at centrosomes during mitosis.,subunit:Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.,tissue specificity:Isoform 1, isoform 3 and isoform 5 a
Protein name
Transforming acidic coiled-coil-containing protein 1
Other name
TACC1; KIAA1103; Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1
Human protein sequence Database
O75410
Mouse protein sequence database
Q6Y685
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .; [Isoform 5]: Membrane ; Lipid-anchor .; [Isoform 10]: Cytoplasm .
Tissue expression
Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
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