Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TOB1. AA range:130-179
Specificity
TOB1 Polyclonal Antibody detects endogenous levels of TOB1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Function
function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.,PTM:Phosphorylated on Ser and Thr residues.,similarity:Belongs to the BTG family.,subunit:Interacts with CNOT7.,tissue specificity:Ubiquitous.,
Protein name
Protein Tob1
Other name
TOB1; TOB; TROB1; Protein Tob1; Transducer of erbB-2 1
Human protein sequence Database
P50616
Mouse protein sequence database
Q61471
Rat protein sequence database
Q8R5K6
Cellular localization
Cytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .
Tissue expression
Ubiquitous.
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