Immunogen
Purified recombinant fragment of ApoO expressed in E. Coli.
Specificity
ApoO Monoclonal Antibody detects endogenous levels of ApoO protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009],
Function
function:Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.,PTM:O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.,similarity:Belongs to the apolipoprotein O family.,tissue specificity:Expressed in all tissues examined. Up-regulated in diabetic heart.,
Protein name
Apolipoprotein O
Other name
APOO; FAM121B; My025; Apolipoprotein O; Protein FAM121B
Human protein sequence Database
Q9BUR5
Mouse protein sequence database
Q9DCZ4
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Single-pass membrane protein . Secreted . Mitochondrion . Golgi apparatus membrane . Endoplasmic reticulum membrane . Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. .
Tissue expression
Expressed in all tissues examined. Up-regulated in diabetic heart.
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