Molecular weight (DA)
16kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CRABP2. AA range:41-90
Specificity
CRABP-II Polyclonal Antibody detects endogenous levels of CRABP-II protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010],
Function
domain:Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.,function:Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.,induction:By retinoic acid.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,subcellular location:Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.,subunit:Interacts with RXR and RARA (By similarity). Interacts with importin alpha.,
Protein name
Cellular retinoic acid-binding protein 2
Other name
CRABP2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II
Human protein sequence Database
P29373
Mouse protein sequence database
P22935
Rat protein sequence database
P51673
Cellular localization
Cytoplasm. Endoplasmic reticulum. Nucleus. Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Tissue expression
Colon,Placenta,
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