Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GLUT1. AA range:441-490
Specificity
Glut1 Polyclonal Antibody detects endogenous levels of Glut1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013],
Function
disease:Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]; also called blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.,disease:Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.,function:Facilitative g
Protein name
Solute carrier family 2 facilitated glucose transporter member 1
Other name
SLC2A1; GLUT1; Solute carrier family 2; facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter
Fields
>>HIF-1 signaling pathway;>>Insulin secretion;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Bile secretion;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Renal cell carcinoma;>>Central carbon metabolism in cancer;>>Diabetic cardiomyopathy
Human protein sequence Database
P11166
Mouse protein sequence database
P17809
Rat protein sequence database
P11167
Cellular localization
Cell membrane ; Multi-pass membrane protein . Melanosome . Photoreceptor inner segment . Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Tissue expression
Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车