Molecular weight (DA)
15kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NUTF2. AA range:67-116
Specificity
NTF2 Polyclonal Antibody detects endogenous levels of NTF2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016],
Function
function:Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.,similarity:Contains 1 NTF2 domain.,subunit:Homodimer.,
Protein name
Nuclear transport factor 2
Other name
NUTF2; NTF2; Nuclear transport factor 2; NTF-2; Placental protein 15; PP15
Human protein sequence Database
P61970
Mouse protein sequence database
P61971
Rat protein sequence database
P61972
Cellular localization
Cytoplasm, cytosol . Nucleus outer membrane . Nucleus, nuclear pore complex . Nucleus inner membrane . Nucleus, nucleoplasm . At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. .
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