Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from human C/EBP β (Acetyl Lys265)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat C/EBP β (Acetyl Lys265)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'.,PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2.,tissue specificity:Expressed at low levels in the lung, kidney and spleen.,
Function
in utero embryonic development, regulation of cytokine production, placenta development, embryonic placenta development, acute inflammatory response, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, anti-apoptosis, induction of apoptosis, defense response, acute-phase response, inflammatory response,immune response, response to wounding, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, positive regulation of cell death, induction of programmed cell death, neuron differentiation, positive regulation of cellular bios
Gene Name
CEBPB LAP TCF5 PP9092
Protein name
C/EBP β (Acetyl Lys265)
Other name
CCAAT/enhancer-binding protein beta (C/EBP beta;Liver activator protein;Nuclear factor NF-IL6;Transcription factor 5;TCF-5)
Fields
>>IL-17 signaling pathway;>>TNF signaling pathway;>>Tuberculosis;>>Transcriptional misregulation in cancer
Human protein sequence Database
P17676
Mouse protein sequence database
P28033
Rat protein sequence database
P21272
Cellular localization
Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). .
Tissue expression
Expressed at low levels in the lung, kidney and spleen.
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