Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human INT4 AA range: 10-60
Specificity
This antibody detects endogenous levels of INT4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.262% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008],
Function
function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,similarity:Belongs to the Integrator subunit 4 family.,similarity:Contains 8 HEAT repeats.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,
Other name
Integrator complex subunit 4 (Int4)
Human protein sequence Database
Q96HW7
Mouse protein sequence database
Q8CIM8
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Aorta,Brain,Muscle,Ovary,Uterus,
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