Molecular weight (DA)
90kD
Immunogen
Synthesized peptide derived from human Sp1 (Acetyl Lys703)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat Sp1 (Acetyl Lys703)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter.,PTM:O-glycosylated; contains N-acetylglucosamine side chains.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.,
Function
skeletal system development, ossification, eye development, in utero embryonic development, blastocyst development, blastocyst formation, trophectodermal cell differentiation, liver development, placenta development,embryonic placenta development, immune system development, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, global, sensory organ development, female pregnancy, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, hemopoiesis,myeloid cell differentiation, erythrocyte differentiation, megakaryocyte differentiation, respiratory tube development,lung
Protein name
Sp1 (Acetyl Lys703)
Other name
Transcription factor Sp1
Fields
>>Endocrine resistance;>>Mitophagy - animal;>>TGF-beta signaling pathway;>>Estrogen signaling pathway;>>Cortisol synthesis and secretion;>>Parathyroid hormone synthesis, secretion and action;>>Cushing syndrome;>>Huntington disease;>>Spinocerebellar ataxia;>>Human cytomegalovirus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Breast cancer;>>Choline metabolism in cancer;>>Diabetic cardiomyopathy
Human protein sequence Database
P08047
Mouse protein sequence database
O89090
Rat protein sequence database
Q01714
Cellular localization
Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Tissue expression
Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.
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