Molecular weight (DA)
60kD
Immunogen
Purified recombinant human GATA6 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of GATA6 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012],
Function
function:Thought to be important for regulating terminal differentiation and/or proliferation.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:Expressed in heart, gut and gut-derived tissues.,
Other name
Gata binding factor 6;Gata binding protein 6;GATA-binding factor 6;Gata6;GATA6_HUMAN; Transcription factor Gata 6;Transcription factor GATA-6.
Human protein sequence Database
Q92908
Mouse protein sequence database
Q61169
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in heart, gut and gut-derived tissues. Expressed in skin upper pilosebaceous unit. Expression is decreased or lost in acne lesions (PubMed:33082341).
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