Molecular weight (DA)
58kD
Immunogen
Purified recombinant human Ikaros(C-terminus) protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of Ikaros(C-terminus) and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding
Function
function:Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.,
Other name
CLL associated antigen KW 6;DNA-binding protein Ikaros;hIk 1;hIk-1;Hs.54452;IK1;Ikaros (zinc finger protein);IKAROS;IKAROS family zinc finger 1 (Ikaros);Ikaros family zinc finger protein 1;Ikzf1;IKZF1_HUMAN;LYF1;Lymphoid transcription factor LyF-1;PRO0758;Zinc finger protein subfamily 1A 1 (Ikaros);zinc finger protein subfamily 1A 1;Zinc finger protein, subfamily 1A, member 1;ZNFN1A1.
Human protein sequence Database
Q13422
Mouse protein sequence database
Q03267
Rat protein sequence database
Cellular localization
Nucleus . In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events. .; [Isoform Ik2]: Nucleus. In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). .; [Isoform Ik6]: Cytoplasm .
Tissue expression
Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.
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