Molecular weight (DA)
33kD
Immunogen
The antiserum was produced against synthesized peptide derived from human JunB around the phosphorylation site of Ser259. AA range:226-275
Specificity
Phospho-Jun B (S259) Polyclonal Antibody detects endogenous levels of Jun B protein only when phosphorylated at S259.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.,induction:By growth factors.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as an homodimer or as an heterodimer with another member of the jun/fos family.,
Function
function:Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.,induction:By growth factors.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as an homodimer or as an heterodimer with another member of the jun/fos family.,
Protein name
Transcription factor jun-B
Other name
JUNB; Transcription factor jun-B
Fields
>>Osteoclast differentiation;>>TNF signaling pathway;>>Growth hormone synthesis, secretion and action
Human protein sequence Database
P17275
Mouse protein sequence database
P09450
Rat protein sequence database
P24898
Cellular localization
Nucleus.
Tissue expression
Adipose tissue,Epithelium,Pancreas,Placenta,Prostat
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