Molecular weight (DA)
52kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BMP-5. AA range:114-163
Specificity
BMP-5 Polyclonal Antibody detects endogenous levels of BMP-5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016],
Function
function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 5 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in the lung and liver.,
Protein name
Bone morphogenetic protein 5
Other name
BMP5; Bone morphogenetic protein 5; BMP-5
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway
Human protein sequence Database
P22003
Mouse protein sequence database
P49003
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in the lung and liver.
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