Molecular weight (DA)
42,also have 30kd isform
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human C/EBP α (phospho Thr230)
Specificity
Phospho-C/EBP α (T230) Polyclonal Antibody detects endogenous levels of C/EBP α protein only when phosphorylated at T230.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],
Function
function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X.,
Protein name
CCAAT/enhancer-binding protein alpha
Other name
CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha
Fields
>>Non-alcoholic fatty liver disease;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia
Human protein sequence Database
P49715
Mouse protein sequence database
P53566
Rat protein sequence database
P05554
Cellular localization
Nucleus .; [Isoform 4]: Nucleus, nucleolus .
Tissue expression
Liver,Pancreas,Umbilical cord,White Matter pool- 5 brain tissues- f
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