Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KAD6. AA range:11-60
Specificity
AK6 Polyclonal Antibody detects endogenous levels of AK6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
adenylate kinase 6(AK6) Homo sapiens This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function
regulation of cell growth, chromatin organization, transcription, transcription, DNA-dependent, transcription initiation,RNA elongation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter,RNA elongation from RNA polymerase II promoter, protein complex assembly, protein amino acid acetylation,regulation of cell size, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, response to organic substance, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative
Protein name
Adenylate kinase isoenzyme 6
Other name
TAF9; AK6; CINAP; AD-004; CGI-137; Adenylate kinase isoenzyme 6; ATP-AMP transphosphorylase 6; Coilin-interacting nuclear ATPase protein; hCINAP
Fields
>>Purine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors;>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
Q9Y3D8
Mouse protein sequence database
Q8VCP8
Rat protein sequence database
Q5EB68
Cellular localization
Nucleus, nucleoplasm. Nucleus, Cajal body. Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.
Tissue expression
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.
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