Immunogen
The antiserum was produced against synthesized peptide derived from human ZMY11. AA range:111-160
Specificity
BS69 Polyclonal Antibody detects endogenous levels of BS69 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
function:Binds to the transactivation domain of the adenovirus type 5 E1A 32 kDa protein (289R) and inhibits its transactivating activity. May act as tumor suppressor through suppression of adenovirus replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 bromo domain.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 PWWP domain.,
Protein name
Zinc finger MYND domain-containing protein 11
Other name
ZMYND11; BS69; Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Protein BS69
Human protein sequence Database
Q15326
Mouse protein sequence database
Q8R5C8
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Associates with chromatin and mitotic chromosomes. .
Tissue expression
Ubiquitous.
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