Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human APOBEC3D/F. AA range:232-281
Specificity
APOBEC3D/F Polyclonal Antibody detects endogenous levels of APOBEC3D/F protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008],
Function
cofactor:Zinc.,function:Unknown. Unable to reduce HIV-1 infectivity in vitro.,miscellaneous:It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,
Gene Name
APOBEC3D/APOBEC3F
Protein name
Probable DNA dC->dU-editing enzyme APOBEC-3D/F
Other name
APOBEC3D; Probable DNA dC->dU-editing enzyme APOBEC-3D; APOBEC3F; DNA dC->dU-editing enzyme APOBEC-3F; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F
Fields
>>Viral life cycle - HIV-1;>>Human immunodeficiency virus 1 infection
Human gene ID
200316/140564
Human protein sequence Database
Q96AK3/Q8IUX4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm. Cytoplasm, P-body.
Tissue expression
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung.
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