Molecular weight (DA)
34kD
Immunogen
The antiserum was produced against synthesized peptide derived from human C/EBP-epsilon. AA range:40-89
Specificity
C/EBP ε Polyclonal Antibody detects endogenous levels of C/EBP ε protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008],
Function
function:C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,online information:CEBPE mutation db,PTM:Phosphorylated.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.,tissue specificity:Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.,
Protein name
CCAAT/enhancer-binding protein epsilon
Other name
CEBPE; CCAAT/enhancer-binding protein epsilon; C/EBP epsilon
Fields
>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia
Human protein sequence Database
Q15744
Mouse protein sequence database
Q6PZD9
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.
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