Molecular weight (DA)
120kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CEBPZ. AA range:1-50
Specificity
C/EBP ζ Polyclonal Antibody detects endogenous levels of C/EBP ζ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016],
Function
function:Stimulates transcription from the HSP70 promoter.,similarity:Belongs to the CBF/MAK21 family.,
Protein name
CCAAT/enhancer-binding protein zeta
Other name
CEBPZ; CBF2; CCAAT/enhancer-binding protein zeta; CCAAT-box-binding transcription factor; CBF; CCAAT-binding factor
Human protein sequence Database
Q03701
Mouse protein sequence database
P53569
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Epithelium,Testis,
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