Molecular weight (DA)
63kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AATF. AA range:10-59
Specificity
Che-1 Polyclonal Antibody detects endogenous levels of Che-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008],
Function
function:May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.,PTM:Hyperphosphorylated during the G1/S phase transition.,similarity:Belongs to the AATF family.,subunit:Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.,tissue specificity:Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.,
Protein name
Protein AATF
Other name
AATF; CHE1; DED; HSPC277; Protein AATF; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
Human protein sequence Database
Q9NY61
Mouse protein sequence database
Q9JKX4
Rat protein sequence database
Q9QYW0
Cellular localization
Nucleus, nucleolus .
Tissue expression
Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
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