Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CNOT7. AA range:10-59
Specificity
CNOT7 Polyclonal Antibody detects endogenous levels of CNOT7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CCR4-NOT transcription complex subunit 7(CNOT7) Homo sapiens The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016],
Function
function:Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.,similarity:Belongs to the CAF1 family.,subunit:Interacts with TOB1.,
Protein name
CCR4-NOT transcription complex subunit 7
Other name
CNOT7; CAF1; CCR4-NOT transcription complex subunit 7; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1
Human protein sequence Database
Q9UIV1
Mouse protein sequence database
Q60809
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .
Tissue expression
Embryo,Lymph,Placenta,Prostate,Testis,
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