Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CTDSP1. AA range:1-50
Specificity
CTDSP1 Polyclonal Antibody detects endogenous levels of CTDSP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CTD small phosphatase 1(CTDSP1) Homo sapiens This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],
Function
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,similarity:Contains 1 FCP1 homology domain.,subunit:May interact with LDB1 .,tissue specificity:Ubiquitously expressed, with highest expression in spleen, lung and placenta.,
Protein name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Other name
CTDSP1; NIF3; NLIIF; SCP1; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD ph
Human protein sequence Database
Q9GZU7
Mouse protein sequence database
P58466
Rat protein sequence database
Cellular localization
Nucleus . Colocalizes with RNA polymerase II.
Tissue expression
Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
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