Molecular weight (DA)
18kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ECP. AA range:102-151
Specificity
ECP Polyclonal Antibody detects endogenous levels of ECP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014],
Function
disease:Induces the neurotoxic effect known as the Gordon phenomenon.,function:Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.,similarity:Belongs to the pancreatic ribonuclease family.,subcellular location:Matrix of eosinophil's large specific granule.,
Protein name
Eosinophil cationic protein
Other name
RNASE3; ECP; RNS3; Eosinophil cationic protein; ECP; Ribonuclease 3; RNase 3
Human protein sequence Database
P12724
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted. Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Tissue expression
Colon,Fetal liver,Peripheral blood granulocyte,
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