Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FOXJ1. AA range:271-320
Specificity
FoxJ1 Polyclonal Antibody detects endogenous levels of FoxJ1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009],
Function
developmental stage:Expressed in developing lung, kidney and central nervous system.,disease:Genetic variations in FOXJ1 may be associated with susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.,function:May play an important role in cell fate determination during lung development and in spermatogenesis.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Testis, oviduct, lung and brain cortex.,
Protein name
Forkhead box protein J1
Other name
FOXJ1; FKHL13; HFH4; Forkhead box protein J1; Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4
Human protein sequence Database
Q92949
Mouse protein sequence database
Q61660
Rat protein sequence database
Q63247
Cellular localization
Nucleus .
Tissue expression
Testis, oviduct, lung and brain cortex.
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