Molecular weight (DA)
27kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HMGB2. AA range:131-180
Specificity
HMG-2 Polyclonal Antibody detects endogenous levels of HMG-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008],
Function
function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET.,
Protein name
High mobility group protein B2
Other name
HMGB2; HMG2; High mobility group protein B2; High mobility group protein 2; HMG-2
Human protein sequence Database
P26583
Mouse protein sequence database
P30681
Rat protein sequence database
P52925
Cellular localization
Nucleus . Chromosome . Cytoplasm . Secreted . In basal state predominantly nuclear. .
Tissue expression
Expressed in gastric and intestinal tissues (at protein level).
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