Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
NOXA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Function
developmental stage:Expressed in fetal kidney.,domain:The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.,domain:The TPR repeats mediate interaction with RAC1.,function:Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.,PTM:Interaction with YWHAZ depends on phosphorylation by PKA.,similarity:Belongs to the NCF2/NOXA1 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 TPR repeats.,subcellular location:Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric comple
Protein name
NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox)
Human protein sequence Database
Q86UR1
Mouse protein sequence database
Q8CJ00
Rat protein sequence database
A7E3N7
Cellular localization
Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Tissue expression
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
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