Molecular weight (DA)
54kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NRF1. AA range:221-270
Specificity
NRF-1 Polyclonal Antibody detects endogenous levels of NRF-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014],
Function
function:Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.,PTM:Phosphorylation enhances DNA binding.,similarity:Belongs to the NRF1/Ewg family.,subunit:Homodimer. Binds DNA as a dimer. Interacts with PPRC1.,tissue specificity:Ubiquitously expressed with strongest expression in skeletal muscle.,
Protein name
Nuclear respiratory factor 1
Other name
NRF1; Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal
Fields
>>Apelin signaling pathway;>>Huntington disease
Human protein sequence Database
Q16656
Mouse protein sequence database
Q9WU00
Rat protein sequence database
Q62792
Cellular localization
Nucleus.
Tissue expression
Ubiquitously expressed with strongest expression in skeletal muscle.
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