Molecular weight (DA)
100,120kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ORC1L. AA range:331-380
Specificity
ORC1 Polyclonal Antibody detects endogenous levels of ORC1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcr
Function
function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,similarity:Belongs to the ORC1 family.,similarity:Contains 1 BAH domain.,subunit:ORC is composed of six subunits. Interacts with CDC6 and MYST2/HBO1.,
Protein name
Origin recognition complex subunit 1
Other name
ORC1; ORC1L; PARC1; Origin recognition complex subunit 1; Replication control protein 1
Human protein sequence Database
Q13415
Mouse protein sequence database
Q9Z1N2
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Epithelium,Eye,
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