Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human STEAP1. AA range:31-80
Specificity
STEAP1 Polyclonal Antibody detects endogenous levels of STEAP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008],
Function
cofactor:FAD.,function:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,tissue specificity:Ubiquitously expressed. Highly expressed in prostate tumors.,
Protein name
Metalloreductase STEAP1
Other name
STEAP1; PRSS24; STEAP; Metalloreductase STEAP1; Six-transmembrane epithelial antigen of prostate 1
Fields
>>Mineral absorption
Human protein sequence Database
Q9UHE8
Mouse protein sequence database
Q9CWR7
Rat protein sequence database
Cellular localization
Endosome membrane ; Multi-pass membrane protein .
Tissue expression
Ubiquitously expressed. Highly expressed in prostate tumors.
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