Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PRPF18. AA range:182-231
Specificity
PRPF18 Polyclonal Antibody detects endogenous levels of PRPF18 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008],
Function
function:Participates in the second step of pre-mRNA splicing.,similarity:Belongs to the PRP18 family.,subcellular location:Colocalizes with spliceosomal snRNPs.,subunit:Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.,
Protein name
Pre-mRNA-splicing factor 18
Other name
PRPF18; HPRP18; Pre-mRNA-splicing factor 18; PRP18 homolog; hPRP18
Human protein sequence Database
Q99633
Mouse protein sequence database
Q8BM39
Rat protein sequence database
Q9JKB8
Cellular localization
Nucleus speckle . Colocalizes with spliceosomal snRNPs. .
Tissue expression
Brain,Cervix carcinoma,Placenta,
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