Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RBAK. AA range:1-50
Specificity
RBAK Polyclonal Antibody detects endogenous levels of RBAK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000; IF/ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011],
Function
function:May repress E2F-dependent transcription. May promote AR-dependent transcription.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 KRAB domain.,similarity:Contains 16 C2H2-type zinc fingers.,subunit:Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.,tissue specificity:Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.,
Protein name
RB-associated KRAB zinc finger protein
Other name
RBAK; ZNF769; RB-associated KRAB zinc finger protein; RB-associated KRAB repressor; hRBaK; Zinc finger protein 769
Fields
>>Herpes simplex virus 1 infection
Human protein sequence Database
Q9NYW8
Mouse protein sequence database
Q8BQC8
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.
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