Molecular weight (DA)
56kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RMP. AA range:415-464
Specificity
RMP Polyclonal Antibody detects endogenous levels of RMP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011],
Function
function:Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.,similarity:Belongs to the RNA polymerase II subunit 5-mediating protein family.,subunit:Component of the URI complex that contains PFD2, POLR2E/RPB5, TIP48, TIP49 and URI. Interacts with POLR2E/RPB5 and LRPPRC.,tissue specificity:Ubiquitous.,
Protein name
Unconventional prefoldin RPB5 interactor 1
Other name
URI1; C19orf2; NNX3; PPP1R19; RMP; URI; Unconventional prefoldin RPB5 interactor 1; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein
Human protein sequence Database
O94763
Mouse protein sequence database
Q3TLD5
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite . Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
Tissue expression
Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.
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