Molecular weight (DA)
32kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CCS. AA range:225-274
Specificity
CCS Polyclonal Antibody detects endogenous levels of CCS protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008],
Function
cofactor:Binds 1 zinc ion per subunit.,cofactor:Binds 2 copper ions per subunit.,function:Delivers copper to copper zinc superoxide dismutase (SOD1).,similarity:Contains 1 HMA domain.,similarity:In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.,subunit:Homodimer, and heterodimer with SOD1.,tissue specificity:Ubiquitous.,
Protein name
Copper chaperone for superoxide dismutase
Other name
CCS; Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone
Fields
>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
O14618
Mouse protein sequence database
Q9WU84
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Ubiquitous.
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