Molecular weight (DA)
91kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SOX6. AA range:10-59
Specificity
Sox-6 Polyclonal Antibody detects endogenous levels of Sox-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SRY-box 6(SOX6) Homo sapiens This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009],
Function
function:Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.,PTM:Sumoylation inhibits the transcriptional activity.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interacts with DAZAP2.,tissue specificity:Expressed in a wide variety of tissues, most abundantly in skeletal muscle.,
Protein name
Transcription factor SOX-6
Other name
SOX6; Transcription factor SOX-6
Human protein sequence Database
P35712
Mouse protein sequence database
P40645
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Expressed in a wide variety of tissues, most abundantly in skeletal musclen.
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