Immunogen
Purified recombinant fragment of human BDH1 expressed in E. Coli.
Specificity
BDH1 Monoclonal Antibody detects endogenous levels of BDH1 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
Function
catalytic activity:(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.,enzyme regulation:Requires phosphatidylcholine as an allosteric activator for enzymatic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homotetramer.,
Protein name
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Other name
BDH1; BDH; D-beta-hydroxybutyrate dehydrogenase; mitochondrial; BDH; 3-hydroxybutyrate dehydrogenase
Fields
>>Butanoate metabolism;>>Metabolic pathways
Human protein sequence Database
Q02338
Mouse protein sequence database
Q80XN0
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane . Mitochondrion matrix .
Tissue expression
Heart,Lung,Ovary,
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