Molecular weight (DA)
51kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Tryptophan Hydroxylase around the phosphorylation site of Ser58. AA range:26-75
Specificity
Phospho-TPH1 (S58) Polyclonal Antibody detects endogenous levels of TPH1 protein only when phosphorylated at S58.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009],
Function
catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,subunit:Multimer of identical subunits.,tissue specificity:Isoform 2 seems to be less widely expressed than isoform 1.,
Protein name
Tryptophan 5-hydroxylase 1
Abbreviation
Tryptophan Hydroxylase
Other name
TPH1; TPH; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1
Fields
>>Tryptophan metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Serotonergic synapse
Human protein sequence Database
P17752
Mouse protein sequence database
P17532
Rat protein sequence database
P09810
Cellular localization
cytosol,neuron projection,
Tissue expression
[Isoform 2]: Seems to be less widely expressed than isoform 1.
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