Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPD2. AA range:131-180
Specificity
AMPD2 Polyclonal Antibody detects endogenous levels of AMPD2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
Function
catalytic activity:AMP + H(2)O = IMP + NH(3).,function:AMP deaminase plays a critical role in energy metabolism.,pathway:Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.,similarity:Belongs to the adenosine and AMP deaminases family.,subunit:Homotetramer.,tissue specificity:Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.,
Protein name
AMP deaminase 2
Other name
AMPD2; AMP deaminase 2; AMP deaminase isoform L
Fields
>>Purine metabolism;>>Metabolic pathways;>>Nucleotide metabolism
Human protein sequence Database
Q01433
Mouse protein sequence database
Q9DBT5
Rat protein sequence database
Q02356
Cellular localization
cytosol,
Tissue expression
Highly expressed in cerebellum.
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