Molecular weight (DA)
81kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CAPN11. AA range:401-450
Specificity
Calpain 11 Polyclonal Antibody detects endogenous levels of Calpain 11 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008],
Function
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis.,
Other name
CAPN11; Calpain-11; Calcium-activated neutral proteinase 11; CANP 11
Human protein sequence Database
Q9UMQ6
Mouse protein sequence database
Q6J756
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle, secretory vesicle, acrosome .
Tissue expression
Highest expression in testis.
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